Molecular Mechanism for Selective Toxicity of Nicotinoids and Neonicotinoids
نویسنده
چکیده
the corresponding one ef neonicotinoids indicated that the latter was far deshielded as compared with the forrner. The result implies that the unsharcd electron pair on the concerned nitrogcn atom is delocalized by the presencc of strang electTon-withdrawing group and the nitrogen atom becomes partially positivc. Such nitrogen is enough to interact with the insect nAChR, but not with the vertebrate ene. The overall results explain why nicotine is highly toxic to marnmals and rather limited in insecticidal activity, whereas imidacloprid is highly insecticidal and low in mammalian toxicitv.
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تاریخ انتشار 2017